BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia.

ABSTRACT:

Background

BCL2 protein inhibitor venetoclax (ABT-199) has been authorized by Food and Drug Administration for relapsed/refractory chronic lymphoid leukemia with 17p deletion. Although venetoclax/ABT-199 also caused cell death in acute myeloid leukemia (AML), whether it could be applied to clinical treatment needs further studies. Here, we revealed clinical implication of BCL2 overexpression in de novo adult AML, and may provide theoretical basis for targeted therapy using venetoclax.

Methods

BCL2 expression was analyzed in adult AML patients from public datasets The Cancer Genome Atlas (TCGA) and confirmed by another independent cohort from our own data.

Results

BCL2 expression showed up-regulated in AML patients among TCGA data and confirmed by our own data. BCL2 ov

SUBMITTER: Zhou JD 

PROVIDER: S-EPMC6599255 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature