Inflammatory profiling of patients with familial amyloid polyneuropathy.

ABSTRACT:

Background

Familial amyloid polyneuropathy (FAP) or ATTRv (amyloid TTR variant) amyloidosis is a fatal hereditary disease characterized by the deposition of amyloid fibrils composed of transthyretin (TTR). The current diagnosis of ATTRv relies on genetic identification of TTR mutations and on Congo Red-positive amyloid deposits, which are absent in most ATTRv patients that are asymptomatic or early symptomatic, supporting the need for novel biomarkers to identify patients in earlier disease phases allowing disease control.

Methods

In an effort to search for new markers for ATTRv, our group searched for nine inflammation markers in ATTRv serum from a cohort of 28 Brazilian ATTRv patients.

Results

We found that the levels of six markers were increased (TNF-α, IL-1β, IL-

SUBMITTER: Azevedo EP 

PROVIDER: S-EPMC6599258 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature