Ridge regression estimated linear probability model predictions of O-glycosylation in proteins with structural and sequence data.

ABSTRACT:

Background

To-date, no claim regarding finding a consensus sequon for O-glycosylation has been made. Thus, predicting the likelihood of O-glycosylation with sequence and structural information using classical regression analysis is quite difficult. In particular, if a binary response is used to distinguish between O-glycosylated and non-O-glycosylated sequences, an appropriate set of non-O-glycosylatable sequences is hard to find.

Results

Three sequences from similar post-translational modifications (PTMs) of proteins occurring at, or very near, the S/T-site are analyzed: N-glycosylation, O-mucin type (O-GalNAc) glycosylation, and phosphorylation. Results found include: 1) The consensus composite sequon for O-glycosylation is: ~(W-S/T-W), where "~" denotes the "not" operator

SUBMITTER: Gana R 

PROVIDER: S-EPMC6599295 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature