Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets. We aimed to explore some novel genes and pathways related to TNBC prognosis through bioinformatics methods as well as potential initiation and progression mechanisms.

Methods

Breast cancer mRNA data were obtained from The Cancer Genome Atlas database (TCGA). Differential expression analysis of cancer and adjacent cancer, as well as, triple negative breast cancer and non-triple negative breast cancer were performed using R software. The key genes related to the pathogenesis were identified by functional and pathway enrichment analysis and protein-protein interaction network analysis. Based on u

SUBMITTER: Lv X 

PROVIDER: S-EPMC6599314 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature