Cognitive Implications of Ototoxicity in Pediatric Patients With Embryonal Brain Tumors.

ABSTRACT:

Purpose

Sensorineural hearing loss (SNHL) is associated with intellectual and academic declines in children treated for embryonal brain tumors. This study expands upon existing research by examining core neurocognitive processes that may result in reading difficulties in children with treatment-related ototoxicity.

Patients and methods

Prospectively gathered, serial, neuropsychological and audiology data for 260 children and young adults age 3 to 21 years (mean, 9.15 years) enrolled in a multisite research and treatment protocol, which included surgery, risk-adapted craniospinal irradiation (average risk, n = 186; high risk, n = 74), and chemotherapy, were analyzed using linear mixed models. Participants were assessed at baseline and up to 5 years after diagnosis and grouped

SUBMITTER: Olivier TW 

PROVIDER: S-EPMC6599406 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature