Screening of caspase-3 inhibitors from natural molecule database using e-pharmacophore and docking studies.

ABSTRACT: Caspase a protease family member, have a vital role in cell death and inflammation process. Caspase-3, an effector caspase controls the regulation of apoptosis and has an anti apoptotic function. The mechanical significance of restoring apoptosis signaling to selectively target malignant cells is utilized to develop strong therapeutic strategies by the caspase family of mortality - induction molecules. Caspase-3 has currently no clear role in treatment for tumor progression and tumor sensitivity. The present study was aimed to screen caspase for potential inhibitors using computer aided docking methodologies. For this, zinc natural molecule database molecules were screened using e-pharmacophore and ADME protocols along with docking studies. Docking analysis selected two molecules, namely Z

SUBMITTER: Eda SR 

PROVIDER: S-EPMC6599438 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature