Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

ABSTRACT:

Background & aims

Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of chronic liver disease in the United States.

Methods

Participants from the Coronary Artery Risk Development in Young Adults cohort study who delivered ≥ 1 child post-baseline (Y0: 1985-1986), and underwent CT quantification of hepatic steatosis 25 years following cohort entry (Y25: 2010-2011) were included (n = 844). The duration of lactation was summed for all post-baseline births, and NAFLD at Y25 was assessed by central review of CT images and defined by liver attenuation ≤ 40 Hounsfield Units after exclu

SUBMITTER: Ajmera VH 

PROVIDER: S-EPMC6599460 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature