LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway.

ABSTRACT:

Background

Studies have shown that cancer susceptibility candidate 11 (CASC11), a newly discovered long non-coding RNA (lncRNA), was aberrantly overexpressed in hepatic carcinoma, gastric cancer and colorectal cancer. However, its effects on cervical cancer has been kept unknown up to now. The present study was aimed to investigate the relationship between lncRNA CASC11 and cervical cancer and further explore the mechanism of CASC11 effect on cervical cancer progression.

Materials

Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the expressions of CASC11 in cancerous and adjacent normal tissues of patients with cervical cancer as well as in cell lines. The proliferation, migration, invasion and apoptosis were assayed after transfecting the cell w

SUBMITTER: Hsu W 

PROVIDER: S-EPMC6599525 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature