Nuclear envelope assembly defects link mitotic errors to chromothripsis.

ABSTRACT: Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases¹. Micronuclei, one common nuclear aberration, are an origin for chromothripsis², a catastrophic mutational process that is commonly observed in cancer^3-5. Chromothripsis occurs after micronuclei spontaneously lose nuclear envelope integrity, which generates chromosome fragmentation⁶. Disruption of the nuclear envelope exposes DNA to the cytoplasm and initiates innate immune proinflammatory signalling⁷. Despite its importance, the basis of the fragility of the micronucleus nuclear envelope  is not known. Here we show that micronuclei undergo defective nuclear envelope assembly. Only 'core' nuclear envelope proteins^8,9

SUBMITTER: Liu S 

PROVIDER: S-EPMC6599625 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature