Parenting Interacts with Oxytocin Polymorphisms to Predict Adolescent Social Anxiety Symptom Development: A Novel Polygenic Approach.

ABSTRACT: Guided by a developmental psychopathology framework, research has increasingly focused on the interplay of genetics and environment as a predictor of different forms of psychopathology, including social anxiety. In these efforts, the polygenic nature of complex phenotypes such as social anxiety is increasingly recognized, but studies applying polygenic approaches are still scarce. In this study, we applied Principal Covariates Regression as a novel approach to creating polygenic components for the oxytocin system, which has recently been put forward as particularly relevant to social anxiety. Participants were 978 adolescents (49.4% girls; M_age T₁ = 13.8 years). Across 3 years, questionnaires were used to assess adolescent social anxiety symptoms and multi-informant r

SUBMITTER: Nelemans SA 

PROVIDER: S-EPMC6599763 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature