Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model.

ABSTRACT: The glycocalyx has been identified as a key mechano-sensor of the shear forces exerted by streaming blood onto the vascular endothelial lining. Although the biochemical reaction to the blood flow has been extensively studied, the mechanism of transmission of the haemodynamic shear forces to the endothelial transmembrane anchoring structures and, consequently, to the subcellular elements in the cytoskeleton, is still not fully understood. Here we apply a multiscale approach to elucidate how haemodynamic shear forces are transmitted to the transmembrane anchors of endothelial cells. Wall shear stress time histories, as obtained from image-based computational haemodynamics models of a carotid bifurcation, are used as a load and a continuum model is applied to obtain the mechanical response of

SUBMITTER: Saez P 

PROVIDER: S-EPMC6599767 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature