Modulation of β-amyloid aggregation by graphene quantum dots.

ABSTRACT: Misfolding and abnormal aggregation of β-amyloid peptide is associated with the onset and progress of Alzheimer's disease (AD). Therefore, modulating β-amyloid aggregation is critical for the treatment of AD. Herein, we studied the regulatory effects and mechanism of graphene quantum dots (GQDs) on 1-42 β-amyloid (Aβ_1-42) aggregation. GQDs displayed significant regulatory effects on the aggregation of Aβ_1-42 peptide as detected by thioflavin T (ThT) assay. Then, the changes of confirmations and structures induced by GQDs on the Aβ_1-42 aggregation were monitored by circular dichroism (CD), dynamic light scattering (DLS) and transmission electron microscope (TEM). The in vitro cytotoxicity experiments further demonstrated the feasibility of GQDs on the

SUBMITTER: Liu C 

PROVIDER: S-EPMC6599798 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature