C-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.

ABSTRACT: The tumor microenvironment may alter the original tumorigenic potential of tumor cells. Under harsh environmental conditions, genetic alterations conferring selective advantages may initiate the growth of tumor subclones, providing new opportunities for these tumors to grow. We performed a genetic loss-of-function screen to identify genetic alterations able to promote tumor cell growth in the absence of glucose. We identified that downregulation of MYBBP1A increases tumorigenic properties under nonpermissive conditions. MYBBP1A downregulation simultaneously activates PGC1α, directly by alleviating direct repression and indirectly by increasing PGC1α mRNA levels through c-MYB, leading to a metabolic switch from glycolysis to OXPHOS and increased tumorigenesis in low-glucose microenvironment

SUBMITTER: Felipe-Abrio B 

PROVIDER: S-EPMC6599841 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature