Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum.

ABSTRACT:

Background

Several neurodegeneration (N) metrics using structural MRI are used for the purpose of Alzheimer's disease (AD)-related staging, including hippocampal volume, global atrophy, and an "AD signature" composite consisting of thickness or volumetric estimates derived from regions impacted early in AD. This study sought to determine if less user-intensive estimates of global atrophy and hippocampal volume were equivalent to a thickness-based AD signature from FreeSurfer for defining N across the AD continuum (i.e., individuals who are amyloid-positive (A+)).

Methods

Cognitively unimpaired (CU) late middle-aged and older adults, as well as A+ mild cognitive impairment (MCI) and A+ AD dementia individuals, with available CSF and structural MRI scan <1.5 years apart, were

SUBMITTER: Allison SL 

PROVIDER: S-EPMC6599872 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature