Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells.

ABSTRACT: BACKGROUND:We previously reported the frequent neurofibromatosis 2 (NF2) gene mutations in anaplastic thyroid cancers in association with the BRAFV600E mutation. We aimed to investigate the role of NF2 in thyroid cancer with BRAF mutation. METHODS:To identify the function of NF2 in thyroid cancers, we investigated the changes in cell proliferation, colon formation, migration and invasion of thyroid cancer cells (8505C, BHT101, and KTC-1) with BRAFV600E mutation after overexpression and knock-down of NF2. We also examined how cell proliferation changed when NF2 was mutagenized. Human NF2 expression in papillary thyroid carcinoma (PTC) was analyzed using the The Cancer Genome Atlas (TCGA) data. RESULTS:First, NF2 was overexpressed in 8505C and KTC-1 cells. Compared to control, NF2 overexpres

SUBMITTER: You MH 

PROVIDER: S-EPMC6599905 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature