Noggin depletion in adipocytes promotes obesity in mice.

ABSTRACT:

Objective

Obesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was to define the role of Noggin, an extracellular BMP inhibitor, in adipogenesis.

Methods

We generated adipose-derived progenitor cells and a mouse model with adipocyte-specific Noggin deletion using the Adiponectin^Cre transgenic mouse, and determined the adipose phenotype of Noggin-deficiency.

Results

Our studies showed that Noggin is expressed in progenitor cells but declines in adipocytes, possibly allowing for lipid accumulation. Correspondingly, adipocyte-speci

SUBMITTER: Blazquez-Medela AM 

PROVIDER: S-EPMC6600080 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature