Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging.

ABSTRACT: Gangliosides are widely expressed in almost all tissues and cells and are also considered to be essential in the development and maintenance of various organs and tissues. However, little is known about their roles in bone metabolism. In this study, we investigated the effects of genetic deletion of ganglioside D3 (GD3) synthase, which is responsible for the generation of all b-series gangliosides, on bone metabolism. Although b-series gangliosides were not expressed in osteoblasts, these gangliosides were expressed in pre-osteoclasts. However, the expression of these gangliosides was decreased after induction of osteoclastogenesis by receptor activator of nuclear factor kappa-B ligand (RANKL). Three-dimensional micro-computed tomography (3D-μCT) analysis revealed that femoral cancellous b

SUBMITTER: Yo S 

PROVIDER: S-EPMC6600367 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature