Systematic Studies on the Protocol and Criteria for Selecting a Covalent Docking Tool.

ABSTRACT: With the resurgence of drugs with covalent binding mechanisms, much attention has been paid to docking methods for the discovery of targeted covalent inhibitors. The existence of many available covalent docking tools has inspired development of a systematic and objective procedure and criteria with which to evaluate these programs. In order to find a tool appropriate to studies of a covalently binding system, protocols and criteria are proposed for protein-ligand covalent docking studies. This paper consists of three sections: (1) curating a standard data set to evaluate covalent docking tools objectively; (2) establishing criteria to measure the performance of a tool applied for docking ligands into a complex system; and (3) creating a protocol to evaluate and select covalent binding tool

SUBMITTER: Wen C 

PROVIDER: S-EPMC6600387 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature