Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes.

ABSTRACT: Scorpion toxins are well-known as the largest potassium channel peptide blocker family. They have been successfully proven to be valuable molecular probes for structural research on diverse potassium channels. The potassium channel pore region, including the turret and filter regions, is the binding interface for scorpion toxins, and structural features from different potassium channels have been identified using different scorpion toxins. According to the spatial orientation of channel turrets with differential sequence lengths and identities, conformational changes and molecular surface properties, the potassium channel turrets can be divided into the following three states: open state with less hindering effects on toxin binding, half-open state or half-closed state with certain effects

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6600638 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature