Uncovering the assembly pathway of human ribosomes and its emerging links to disease.

ABSTRACT: The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation. The fact that numerous diseases are caused by defects in ribosome assembly underscores the importance of obtaining a detailed understanding of this pathway. Studies in yeast have provided a wealth of information about the fundamental principles of ribosome assembly, and although many features are conserved throughout eukaryotes, the larger size of human (pre-)ribosomes, as well as the evolution of additional regulatory networks that can modulate ribosome assembly and function, have resulted in a more complex assembly pathway in humans. Notably, many ribosome biogenesis factors conserved from yeast appear to have subtl

SUBMITTER: Bohnsack KE 

PROVIDER: S-EPMC6600647 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature