Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor.

ABSTRACT:

Background

High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). However, conventional continuous stimulation may deliver unnecessary current to the brain since tremor mainly affects voluntary movements and sustained postures in ET.

Objective

We aim to decode both voluntary movements and the presence of postural tremor from the Local field potentials (LFPs) recorded from the electrode implanted in motor thalamus for stimulation, in order to close the loop for DBS so that stimulation could be delivered on demand, without the need for peripheral sensors or additional invasive electrodes.

Methods

LFPs from the motor thalamus, surface electromyographic (EMG) signals and/or behavioural measurements were simu

SUBMITTER: Tan H 

PROVIDER: S-EPMC6600875 | biostudies-literature | 2019 Jul - Aug

REPOSITORIES: biostudies-literature