Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones.

ABSTRACT:

Background

ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ketone availability.

Methods

In a centrally catheterized, fluid-resuscitated, antibiotic-treated mouse model of prolonged sepsis, we compared markers of lipolysis and fatty acid oxidation in lean and obese septic mice (n = 117). Next, we compared markers of muscle wasting and weakness in septic obese wild-type and adipose tissue-specific ATGL knockout (AAKO) mice (n = 73), in lean septic mice receiving either intravenous infusion of lipids or standard parenteral n

SUBMITTER: Goossens C 

PROVIDER: S-EPMC6600878 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature