Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepod Tigriopus californicus.

ABSTRACT: Hypoxia is a major physiological constraint for which multicellular eukaryotes have evolved robust cellular mechanisms capable of addressing dynamic changes in O₂ availability. In animals, oxygen sensing and regulation is primarily performed by the hypoxia-inducible factor (HIF) pathway, and the key components of this pathway are thought to be highly conserved across metazoans. Marine intertidal habitats are dynamic environments, and their inhabitants are known to tolerate wide fluctuations in salinity, temperature, pH, and oxygen. In this study, we show that an abundant intertidal crustacean, the copepod Tigriopus californicus, has lost major genetic components of the HIF pathway, but still shows robust survivorship and transcriptional response to hypoxia. Mining of prot

SUBMITTER: Graham AM 

PROVIDER: S-EPMC6600937 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature