Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance.

ABSTRACT: Synthesis of triiodothyronine (T₃) in the hypothalamus induces marked seasonal neuromorphology changes across taxa. How species-specific responses to T₃ signaling in the CNS drive annual changes in body weight and energy balance remains uncharacterized. These experiments sequenced and annotated the Siberian hamster (Phodopus sungorus) genome, a model organism for seasonal physiology research, to facilitate the dissection of T₃-dependent molecular mechanisms that govern predictable, robust, and long-term changes in body weight. Examination of the Phodopus genome, in combination with transcriptome sequencing of the hamster diencephalon under winter and summer conditions, and in vivo-targeted expression analyses confirmed that proopiomelanocortin

SUBMITTER: Bao R 

PROVIDER: S-EPMC6600942 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature