Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity.

ABSTRACT: Human cytomegalovirus (HCMV) causes severe disease in infants and immunocompromised people. There is no approved HCMV vaccine, and vaccine development strategies are complicated by evidence of both persistent infection and reinfection of people with prior immunity. The greatest emphasis has been placed on reducing transmission to seronegative pregnant women to prevent vertical transmission and its potentially severe sequelae. Increasing evidence suggests that the earliest host-HCMV interactions establish conditions for viral persistence, including evasion of host immune responses to the virus. Using a nonhuman primate model of HCMV infection, we show that rhesus macaques immunized against viral interleukin-10 (IL-10) manifest delayed rhesus cytomegalovirus (RhCMV) acquisition and altered i

SUBMITTER: Deere JD 

PROVIDER: S-EPMC6601001 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature