Imaging adipose tissue browning using the TSPO-18kDa tracer [¹⁸F]FEPPA.

ABSTRACT:

Objectives

The browning of white adipose tissue (WAT) into beige has been proposed as a strategy to enhance energy expenditure to combat the growing epidemic of obesity. Research into browning strategies are hampered by the lack of sensitive, translatable, imaging tools capable of detecting beige fat mass non-invasively. [¹⁸F]FDG is able to detect activated beige fat but provides little information on unstimulated beige fat mass. We have assessed the use of [¹⁸F]FEPPA, a tracer for the TSPO-18KDa found on the outer mitochondrial membrane, as an alternative imaging agent capable of detecting unstimulated brown fat (BAT) and beige fat.

Methods

Female Balb/c mice (n = 5) were treated for 7 days with the β3 adrenergic agonist CL-316,243 to induce the browni

SUBMITTER: Hartimath SV 

PROVIDER: S-EPMC6601022 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature