Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice.

ABSTRACT: Aminoglycoside ototoxicity is common in clinical practice but reliable protective agents currently do not exist. Aminoglycoside regimens causing ototoxicity in different laboratory animals are under investigation. The assessment method used most commonly to determine auditory effects is the auditory brainstem response (ABR). Distortion product otoacoustic emissions (DPOAE) have been used less frequently. A precise recommendation on the specific method to assess peripheral auditory function before and after aminoglycoside toxicity in mice does not exist. In order to evaluate various mouse models for ototoxic injury caused by various aminoglycoside regimens, there is a need for performing preliminary tests in small cohorts before large experiments. The aim of our study was to investigate dif

SUBMITTER: Horvath L 

PROVIDER: S-EPMC6601143 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature