Gonadal hormones influence core body temperature during calorie restriction.

ABSTRACT: During calorie restriction (CR), endotherms adjust several physiological processes including the decrease of core body temperature (T_b) and reduction of energy expenditure. We recently found that CR-induced hypothermia is regulated in a sex-dependent manner in mice with lowered central insulin-like growth factor receptor signaling. Here, we describe the contribution of sex hormones to CR-induced hypothermia in wild type C57BL6 mice by measuring T_b of female and male mice following bilateral gonadectomy and hormonal replacement. Specifically, we evaluated the effects of progesterone (P4), 17-ß estradiol (E2), a combination of both (P4 + E2) in females and of 5-α dihydrotestosterone (5-α DHT) in males. Gonadectomy resulted in an earlier and stronger CR-induced hypotherm

SUBMITTER: Cintron-Colon R 

PROVIDER: S-EPMC6601541 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature