From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses.

ABSTRACT: The Old World monkey, Rhesus macaque (Macaca mulatta, Mm), is frequently used as a primate model organism in the study of human disease and to test new vaccines/antibody treatments despite diverging before chimpanzees and orangutans. Mm and humans share 93% genome identity with substantial differences in the genes of the adaptive immune system that lead to different functional IgG subclass characteristics, Fcγ receptors expressed on innate immune cells, and biological interactions. These differences put limitations on Mm use as a primary animal model in the study of human disease and to test new vaccines/antibody treatments. Here, we comprehensively analyzed molecular properties of the Fc domain of the four IgG subclasses of Rhesus macaque to describe potential mechanisms for their interac

SUBMITTER: Tolbert WD 

PROVIDER: S-EPMC6601566 | biostudies-literature | 2019 May/Jun

REPOSITORIES: biostudies-literature