Ontology highlight
ABSTRACT:
SUBMITTER: Thomas A
PROVIDER: S-EPMC6601617 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Thomas Anish A Teicher Beverly A BA Hassan Raffit R
The Lancet. Oncology 20160601 6
Antibody-drug conjugates are monoclonal antibodies conjugated to cytotoxic agents. They use antibodies that are specific to tumour cell-surface proteins and, thus, have tumour specificity and potency not achievable with traditional drugs. Design of effective antibody-drug conjugates for cancer therapy requires selection of an appropriate target, a monoclonal antibody against the target, potent cytotoxic effector molecules, and conjugation of the monoclonal antibody to cytotoxic agents. Substanti ...[more]