Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients.

ABSTRACT: Purpose: The cross-talk between tumor cells, myeloid cells, and T cells can play a critical role in tumor pathogenesis and response to immunotherapies. Although the etiology of mesothelioma is well understood, the impact of mesothelioma tumor cells on the surrounding immune microenvironment is less well studied. In this study, the effect of the mesothelioma tumor microenvironment on circulating and infiltrating granulocytes and T cells is investigated.Experimental Design: Tumor tissues and peripheral blood from mesothelioma patients were evaluated for presence of granulocytes, which were then tested for their T-cell suppression potential. Different cocultures of granulocytes and/or mesothelioma tumor cells and/or T cells were set up to identify the mechanism of T-cell inhibit

SUBMITTER: Khanna S 

PROVIDER: S-EPMC6601632 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature