Accumulation of saturated intramyocellular lipid is associated with insulin resistance.

ABSTRACT: Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. ¹H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated ¹H MRS method to compare the compositional saturation index (CH₂:CH₃) and concentration independent of the composition (CH₃) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and heal

SUBMITTER: Savage DB 

PROVIDER: S-EPMC6602127 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature