Age-Related Loss of Human Vitreal Viscoelasticity.

ABSTRACT:

Purpose

To determine the viscoelasticity of human vitreous bodies and its changes with age in order to benefit the understanding and therapy of vitreoretinal diseases.

Methods

In a postmortem study, 190 human vitreous bodies were extracted from 33- to 92-year-old donors, analyzed with regard to their viscoelastic properties via dynamic mechanical analyses, and compared with bovine and porcine vitreous. Postmortem intervals and donor-related parameters were examined as potential parameters influencing vitreous viscoelasticity. Dynamic moduli of different hyaluronic acid (HA) solutions as well as human vitreous treated with HA injections were determined by frequency sweep tests.

Results

With age the viscoelasticity of human vitreous bodies decreased significantly and in

SUBMITTER: Schulz A 

PROVIDER: S-EPMC6602139 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature