Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.

ABSTRACT: C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connections. Most recent efforts are devoted to investigate and clarify the signal processing and functional connectivity, which are at the basis of sensing mechanisms, signal transmission, and motor control. In this framework, a refined modelof whole neuron dynamics constitutes a key ingredient to describe the electrophysiological processes, both at thecellular and at the network scale. In this work, we present Hodgkin-Huxley-based models of ion channels dynamics black, built on data available both from C. elegans and from other organisms, expressing homologous ch

SUBMITTER: Nicoletti M 

PROVIDER: S-EPMC6602206 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature