An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance.

ABSTRACT: Synapse-associated protein 1 (Syap1) is the mammalian homologue of synapse-associated protein of 47 kDa (Sap47) in Drosophila Genetic deletion of Sap47 leads to deficiencies in short-term plasticity and associative memory processing in flies. In mice, Syap1 is prominently expressed in the nervous system, but its function is still unclear. We have generated Syap1 knockout mice and tested motor behaviour and memory. These mice are viable and fertile but display distinct deficiencies in motor behaviour. Locomotor activity specifically appears to be reduced in early phases when voluntary movement is initiated. On the rotarod, a more demanding motor test involving control by sensory feedback, Syap1-deficient mice dramatically fail to adapt to accelerated speed or to a change in rotation directi

SUBMITTER: R von Collenberg C 

PROVIDER: S-EPMC6602322 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature