Yosshi: a web-server for disulfide engineering by bioinformatic analysis of diverse protein families.

ABSTRACT: Disulfide bonds play a significant role in protein stability, function or regulation but are poorly conserved among evolutionarily related proteins. The Yosshi can help to understand the role of S-S bonds by comparing sequences and structures of homologs with diverse properties and different disulfide connectivity patterns within a common structural fold of a superfamily, and assist to select the most promising hot-spots to improve stability of proteins/enzymes or modulate their functions by introducing naturally occurring crosslinks. The bioinformatic analysis is supported by the integrated Mustguseal web-server to construct large structure-guided sequence alignments of functionally diverse protein families that can include thousands of proteins based on all available information in publi

SUBMITTER: Suplatov D 

PROVIDER: S-EPMC6602428 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature