Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.

ABSTRACT: Neural circuits are formed and refined during childhood, including via critical changes in neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We found that dopamine neurotransmission increases from the first to the third postnatal week in mice and precedes the reduction in spiny projection neuron (SPN) intrinsic excitability during the fourth postnatal week. In mice developmentally deficient for striatal dopamine, direct pathway D1-SPNs failed to undergo maturation of excitability past P18 and maintained hyperexcitability into adulthood. We found that the absence of D1-SPN maturation was due to altered phosphatidylinositol 4,5-biphosphate dynamics and a consequent lack of normal ontogenetic increases in Kir2 currents. Dopamine replacement correcte

SUBMITTER: Lieberman OJ 

PROVIDER: S-EPMC6602586 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature