Primary progressive aphasia: a model for neurodegenerative disease.

ABSTRACT:

Purpose of review

Knowledge on primary progressive aphasia (PPA) has expanded rapidly in the past few decades. Clinical characteristics, neuroimaging correlates, and neuropathological features of PPA are better delineated. This facilitates scientific studies on the disease pathophysiology and allows speech and language therapy to be more precisely targeted. This review article begins with a summary of the current understanding of PPA and discusses how PPA can serve as a model to promote scientific discovery in neurodegenerative diseases.

Recent findings

Studies on the different variants of PPA have demonstrated the high compatibility between clinical presentations and neuroimaging features, and in turn, enhances the understanding of speech and language neuroanatomy. In addit

SUBMITTER: Tee BL 

PROVIDER: S-EPMC6602793 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature