Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development.

ABSTRACT:

Background

Mutations in MAB21L2 result in severe ocular defects including microphthalmia, anophthalmia, coloboma, microcornea, and cataracts. The molecular and cellular underpinnings of these defects are unknown, as is the normal cellular function of MAB21L2. Zebrafish mab21l2 ^au10 mutants possess ocular defects resembling those in humans with MAB21L2 mutations, providing an excellent model to characterize mab21l2 functions during eye development.

Results

mab21l2 ^-/- mutants possessed a host of ocular defects including microphthalmia and colobomas as well as small, disorganized lenses and cornea dysgenesis. Decreased proliferation, increased cell death, and defects in marker gene expression were detected in the lens. Cell death in the optic stalk was el

SUBMITTER: Gath N 

PROVIDER: S-EPMC6602828 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature