Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals.

ABSTRACT: The role of innate immunity and macrophages in the host response to biomaterials has received renewed attention. A context-dependent spectrum of macrophage phenotypes are shown to affect tissue integration and performance of implanted biomaterials and medical devices. Recent studies by our group demonstrated that the host response in aged animals was characterized by delayed macrophage recruitment, differences in marker expression and a shifted pro-inflammatory (M1) response, associated with an unresolved host response in the long-term. The present work sought to study the effects of single and sequential cytokine delivery regimens in aged mice to restore delayed recruitment of macrophages and shift the inflammatory host response towards an M2-like phenotype, using MCP-1 (macrophage chemot

SUBMITTER: Hachim D 

PROVIDER: S-EPMC6602858 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature