Replacing Part of Glucose with Galactose in the Postweaning Diet Protects Female But Not Male Mice from High-Fat Diet-Induced Adiposity in Later Life.

ABSTRACT:

Background

Duration of breastfeeding is positively associated with decreased adiposity and increased metabolic health in later life, which might be related to galactose.

Objective

The aim of this study was to investigate if partial replacement of glucose with galactose in the postweaning diet had a metabolic programming effect.

Methods

Male and female mice (C57BL/6JRccHsd) received an isocaloric diet (16 energy% fat; 64 energy% carbohydrates; 20 energy% protein) with either glucose (32 energy%) (GLU) or glucose + galactose (GLU + GAL, 16 energy% each) for 3 wk postweaning. Afterwards, all mice were switched to the same 40 energy% high-fat diet (HFD) for 9 wk to evaluate potential programming effects in an obesogenic environment. Data were analyzed within sex.

Resul

SUBMITTER: Bouwman LMS 

PROVIDER: S-EPMC6602901 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature