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ABSTRACT: Rationale
State-dependent changes in physiological arousal may influence impulsive behaviours.Objectives
To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performance on established laboratory-based impulsivity measures in healthy volunteers.Methods
Forty-three participants received a single dose of either yohimbine hydrochloride or placebo before completing a battery of impulsivity measures. Blood pressure and heart rate were monitored throughout the study.Results
Participants in the yohimbine group showed higher blood pressure and better response inhibition in the Stop Signal Task, relative to
SUBMITTER: Herman AM
PROVIDER: S-EPMC6602985 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature