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The impact of Yohimbine-induced arousal on facets of behavioural impulsivity.


ABSTRACT:

Rationale

State-dependent changes in physiological arousal may influence impulsive behaviours.

Objectives

To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performance on established laboratory-based impulsivity measures in healthy volunteers.

Methods

Forty-three participants received a single dose of either yohimbine hydrochloride or placebo before completing a battery of impulsivity measures. Blood pressure and heart rate were monitored throughout the study.

Results

Participants in the yohimbine group showed higher blood pressure and better response inhibition in the Stop Signal Task, relative to

SUBMITTER: Herman AM 

PROVIDER: S-EPMC6602985 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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