Interaction between lifestyle and genetic susceptibility in myopia: the Generation R study.

ABSTRACT: Myopia is a refractive error of the eye caused by a complex interplay between nature and nurture. The aim of this study was to investigate whether environmental risk factors can influence the genetic effect in children developing myopia. A total of 3422 children participating in the birth-cohort study Generation R underwent an extensive eye examination at 9 years with measurements of refractive error and axial length corneal radius ratio (AL/CR). Environmental risk factors were evaluated using a questionnaire, and environmental risk scores (ERS) were calculated using backward regression analyses. Genetic risk scores (GRS) were calculated based on all currently known risk variants for myopia. Gene-environment interaction (G×E) was investigated using linear and logistic regression analyses.

SUBMITTER: Enthoven CA 

PROVIDER: S-EPMC6602996 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature