Major changes in chromosomal somy, gene expression and gene dosage driven by Sb^III in Leishmania braziliensis and Leishmania panamensis.

ABSTRACT: Leishmania braziliensis and Leishmania panamensis are two species clinically and epidemiologically important, among others because of their relative resistance to first-line drugs (antimonials). The precise mechanism underlying the ability of these species to survive antimony treatment remains unknown. Therefore, elucidating the pathways mediating drug resistance is essential. We herein experimentally selected resistance to trivalent antimony (Sb^III) in the reference strains of L. braziliensis (MHOM/BR75/M2904) and L. panamensis (MHOM/COL/81L13) and compared whole genome and transcriptome alterations in the culture promastigote stage. The results allowed us to identify differences in somy, copy number variations in some genes related to antimony resistance and large-scale copy n

SUBMITTER: Patino LH 

PROVIDER: S-EPMC6603004 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature