Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes).

ABSTRACT: Versican is an evolutionary conserved extracellular matrix proteoglycan, and versican expression loss in mice results in embryonic lethality owing to cardiovascular defects. However, the in utero development of mammals limits our understanding of the precise role of versican during cardiovascular development. Therefore, the use of evolutionarily distant species that develop ex utero is more suitable for studying the mechanistic basis of versican activity. We performed ENU mutagenesis screening to identify medaka mutants with defects in embryonic cardiovascular development. In this study, we described a recessive point mutation in the versican 3'UTR resulting in reduced versican protein expression. The fully penetrant homozygous mutant showed termination of cardiac development at the linear

SUBMITTER: Mittal N 

PROVIDER: S-EPMC6603046 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature