Screening of Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme gene.

ABSTRACT:

Background

/aims: The role of angiotensin-converting enzyme (ACE) gene polymorphism in the development of obesity and hypertension in children has not been widely studied. We aimed to screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the ACE gene.

Methods

One hundred forty-two children and adolescents were included (70 with simple obesity and 72 controls). Blood pressure was measured, and anthropometric parameters were assessed in all included children and adolescents. Fasting lipid profile, fasting glucose, and insulin were measured. DNA extraction and ACE I/D polymorphism genotyping were also performed.

Results

Obese children had a higher frequency of DD genotype (30% in obese versus 11.1% in controls, P = .01) and D

SUBMITTER: El-Kabbany ZA 

PROVIDER: S-EPMC6603068 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature