Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice.

ABSTRACT: Ionizing radiation exposure to the brain is common for patients with a variety of CNS related malignancies. This exposure is known to induce structural and functional alterations to the brain, impacting dendritic complexity, spine density and inflammation. Over time, these changes are associated with cognitive decline. However, many of these impacts are only observable long after irradiation. Extracellular vesicles (EVs) are shed from cells in nearly all known tissues, with roles in many disease pathologies. EVs are becoming an important target for identifying circulating biomarkers. The aim of this study is to identify minimally invasive biomarkers of ionizing radiation damage to the CNS that are predictors of late responses that manifest as persistent cognitive impairments. Using a clini

SUBMITTER: Hinzman CP 

PROVIDER: S-EPMC6603161 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature