Exploring the Use of Pegylated Liposomal Doxorubicin (Caelyx^®) as Pressurized Intraperitoneal Aerosol Chemotherapy.

ABSTRACT: Background: Peritoneal carcinomatosis is a common metastatic pattern in ovarian, gastric, colorectal, and appendiceal cancer; systemic chemotherapy is the current standard of care for peritoneal metastatic disease; however, in a subset of patients its beneficial effect remains questionable. More effective perioperative chemotherapy is needed. Materials and methods: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new treatment that applies chemotherapeutic drugs into the peritoneal cavity as an aerosol under pressure. It's a safe and feasible approach that improves local bioavailability of chemotherapeutic drugs as compared with conventional intraperitoneal chemotherapy. Till now the drugs used in PIPAC for the treatment of the peritoneal carcinomatosis (PC) are

SUBMITTER: Robella M 

PROVIDER: S-EPMC6603215 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature