Gene expression analysis of follicular cells revealed inflammation as a potential IVF failure cause.

ABSTRACT:

Purpose

Hormonal stimulation prior to IVF influences the ovarian environment and therefore impacts oocytes and subsequent embryo quality. Not every patient has the same response to the same treatment and many fail for unknown reasons. Knowing why a cycle has failed and how the follicles were affected would allow clinicians to adapt the treatment accordingly and improve success rate. This study examines the hypothesis that transcriptomic analysis of follicular cells from failed IVF cycles reveals potential reasons for failure and provides new information on the physiological mechanisms related to IVF failure.

Methods

Follicular cells (granulosa cells) were obtained from IVF patients of four Canadian fertility clinics. Using microarray analysis, patients that did not become pr

SUBMITTER: Fortin CS 

PROVIDER: S-EPMC6603252 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature