Value of lung diffusing capacity for nitric oxide in systemic sclerosis.

ABSTRACT: A decreased lung diffusing capacity for carbon monoxide (DL_CO ) in systemic sclerosis (SSc) is considered to reflect losses of alveolar membrane diffusive conductance for CO (DM_CO ), due to interstitial lung disease, and/or pulmonary capillary blood volume (V_C ), due to vasculopathy. However, standard DL_CO does not allow separate DM_CO from V_C . Lung diffusing capacity for nitric oxide (DL_NO ) is considered to be more sensitive to decrement of alveolar membrane diffusive conductance than DL_CO . Standard DL_CO and DL_NO were compared in 96 SSc subjects with or without lung restriction. Data showed that DL_NO was reduced in 22% of subjects with normal lung volumes and DL_C

SUBMITTER: Barisione G 

PROVIDER: S-EPMC6603284 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature